When Alexander the Great died, his empire was carved up. His first generation successors were known as the "diadochi". [See map of the Kingdoms of the Diadochi.] Ptolemy took the Egyptian part, Antigonus took the area in Europe, including Macedonia, and Seleucus took the eastern part, Asia, which he ruled until 281. The Seleucids were the members of the dynasty that ruled Phoenicia, Asia Minor, northern Syria and Mesopotamia. Jona Lendering names the modern states that comprise this area as:
- Afghanistan,
- Iran,
- Iraq,
- Syria,
- Lebanon,
- parts of Turkey, Armenia, Turkmenistan, Uzbekistan, and Tajikistan.
In 64 B.C. the era of Seleucid rule ended when the Roman leader Pompey annexed Syria and Lebanon.

